| MalpLiesmalia | Date: Tuesday, 2012-05-29, 03:13:02 | Message # 1 |
|
Group: Guests
| Michael Kors Outlet Sale Top Quality Michael Kors Milo Bags For People ,Michael Kors Store combinations with dextropropoxyphene (propoxyphene) such as ‘Distalgesic’, ‘Dologesic’ and ‘Co-proxamol’ are particularly dangerous in overdose with regard to sudden death from acute onset respiratory depression due to dextropropoxyphene. Dextropropoxyphene (65 mg of hydrochloride equivalent to 100 mg of napsylate) is a weak opioid analgesic. It is rapidly absorbed, reaching aMichael Kors plasma concentration within 1 hour, with a half-life of 6-12 . It is converted to an active metabolite norpropoxyphene, with a longer half-life (30-36 hours). In overdose, death typically occurs within 1-2 hours and even before hospital treatment can be initiated. Toxicity of dextropropoxyphene is much enhanced by alcohol, benzodiazepines and other CNS depressants. Respiratory failure, CNS depression and convulsions precede death. Cardiotoxicity also contributes to the death. Dextropropoxyphene has sodium channel blocking activity, causing QRS prolongation. VentricularMichael Kors Outlet s, pulmonary edema, asystole and failure have been reported. Some patients sustain hypoxic brain damage before reaching hospital. If the patient with ‘Dologesic’ overdose survives long enough to receive treatment, the CNS and respiratory depressant effects can be reversed by naloxone, which may need to be given in repeated doses. Intensive monitoring is essential in view of the high tissueMichael Kors Bags and slow elimination of dextropropoxyphene metabolite. Overdose of paracetamol should be treated accordingly to prevent liver toxicity.There is a need for more restrictive prescriptionMichael Kors Shop and education for patients to avoid overdose and concurrent use of alcohol and other CNS depressants. 4. Aspirin (salicylates) In acute overdose, the amount of aspirin ingested may predict the risk of potential toxicity and morbidity: Other sources of salicylate poisoning include excessive topical applications and ingestion of medicated oil containing methyl salicylates.Michael Kors Outlet Sale Top Quality Michael Kors Milo Bags For People .
We Offer Great Customer Service And Prompt Shipping On Zip-top Bags,About 5%-15% is converted by cytochrome P450 (chiefly 2E1 and 3A4) to a toxic intermediate, N-acetyl- p-benzoquinone-imine (NAPQI). NAPQI is rapidly detoxified by the thiol groups of hepatic glutathione. In acute overdose or when the maximum daily dose is exceeded over a prolonged period, excessive NAPQI is formed and hepatic glutathione is depleted. NAPQI is then free to bind to other proteins, causing hepatocyte death. If a large amount of paracetamol is taken, massive hepatocellular necrosis ensues. A similar mechanism in the kidney results in renal damage. In the early stage, the patient is often a Michael Kors Grayson atic, apart from some nausea and vomiting. Loss of consciousness indicates that CNS depressantMichael Kors Satchel s (e.g., dextropropoxyphene) have also been taken. If untreated, liver damage may range from mild. Intravenous NAC to prevent liver and renal damage is remarkably effective if given within 8-12 hours. NAC is still beneficial if given at 15-24 hours. Intravenous NAC may cause anaphylactoid (i.e. anaphylactic-like) reactions (mainly rash), especially if the “loading dose” is given over 15 minutes (instead of the 60 minutes).IfMichael Kors Watches reactions occur, withdraw NAC temporarily and restart at slower rate after intravenous administration of an antihistamine with or without hydrocortisone.The main reasons for continuing morbidity andMichael Kors Shoulder Bags due to paracetamol poisoning are failure to give NAC appropriately and lateMichael Kors Watch .”Subacute” poisoning in children (due to prolonged treatment with paracetamol in maximum daily doses which may deplete liver glutathione store) can also result in liver damage.In patients who have ingested unknown drugs and in comatose patients with suspected drug overdose, paracetamol poisoning should always be excluded by urgent measurement of its plasmaShoulder Bags .We Offer Great Customer Service And Prompt Shipping On Zip-top Bags.
|
| |
|
|
